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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647

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1 result(s) for: Viviane do Carmo Vasconcelos de Carvalho

Evaluation of IL-6 (-174 H/C) polymorphism in acute coronary syndrome in the northeast of Brazil

Avaliação do polimorfismo -174 G/C do gene IL-6 na síndrome coronariana aguda no nordeste do Brasil

Viviane do Carmo Vasconcelos de Carvalho; Lílian Caroliny Amorim Silva; Roberto Pereira Werkhauser; Sérgio Tavares Montenegro; Carlos Gustavo Regis da Silva; Adriana Vieira Gomes; Clarice Neuenschwander Lins de Morais; Silvia Maria Lucena Montenegro

Int J Cardiovasc Sci.2016;29(4):288-294 : Original Article


BACKGROUND: Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. It is a multifactorial disease caused by obstruction of the coronary arteries by atheromatous plaques and leads to heart ischemia. Several studies suggest that some genetic polymorphisms change the cytokines levels and influence ACS development.
OBJECTIVE: In this study, we evaluated the IL-6 (-174G/C) polymorphism, serum levels of cytokine and its relationship with ACS and the thrombolysis in myocardial infarction (TIMI) risk score.
MATERIALS AND METHODS: A sample of 200 patients with ACS [TIMI risk - Low (70); Intermediate (89); High (41)] in Brazilian population was used. Genotyping was carried out by polymerase chain reaction, followed by DNA sequencing.
RESULTS: There was no significant differences in genotype (p = 0.53) and allele (p = 0.32) distributions between ACS patient and without ACS patients groups on IL-6 allelic polymorphism and between the three differents TIMI risk score (p > 0.05). Moreover IL-6 polymorphism did not affect the cytokine levels and these levels were not related to TIMI score.
CONCLUSIONS: With these results, we suggest that the IL-6 (-174 G/C) polymorphism, until now, is not related to ACS and did not change the levels of the cytokine in studied population. Further studies with different populations should be done to verify those results. It is important to emphasize that, since ACS is a multifactorial disease, other risk factors and other pro-inflammatory cytokines should be assessed to better understand this pathology. (Int J Cardiovasc Sci. 2016;29(4):288-294)