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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647

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2 result(s) for: Silvia Maria Lucena Montenegro

Comparison of clinical and epidemiological profiles among men and women with acute coronary syndrome

Comparação do perfil clínico-epidemiológico entre homens e mulheres na síndrome coronariana aguda

Maria Celita de Almeida; Carlos Eduardo Lucena Montenegro; Camila Sarteschi; Gabriela Lucena Montenegro; Patricia Bezerra Rocha Montenegro; Jesus Reyes Livera; Silvia Maria Lucena Montenegro; Sergio Tavares Montenegro; Odwaldo Barbosa e Silva; Eduardo Maia Freese de Carvalho

Rev Bras Cardiol.2014;27(6):423-429 : Original Article

Abstract PDF PORT

BACKGROUND: Ischemic heart disease is the leading cause of death among men and women in Brazil and in several countries on different continents. A sharp upsurge in mortality rates has been noted in the developing countries, today constituting a major public health issue.
OBJECTIVE: To analyze and compare the clinical and epidemiological profiles of men and women with acute coronary syndrome.
METHODS: We studied 927 patients (60.0% men) with an average age of 67.0±12.0 years diagnosed with acute coronary syndrome (ACS) and admitted to the coronary unit of a cardiology reference hospital in the supplementary healthcare network between September 2009 and December 2012 in the city of Recife, Pernambuco State, Brazil.
RESULTS: Among the risk factors, hypertension and sedentary lifestyles were more frequent among women (p=0.001), while smoking and alcoholism were more frequent among men (p=0.01). Men also had more frequent acute myocardial infarctions with elevation of the ST segment or previous coronary artery bypass grafting (p=0.011) and higher troponin levels (p=0.006). During hospitalization, adverse outcomes and deaths were more frequent among women (p=0.177).
CONCLUSION: Women with ACS present higher rates for hypertension and sedentary lifestyles, with more adverse outcomes among women underscoring the need for earlier intervention and encouragement for controlling risk factors, in order to lower in-hospital mortality rates with fewer complications.


Evaluation of IL-6 (-174 H/C) polymorphism in acute coronary syndrome in the northeast of Brazil

Avaliação do polimorfismo -174 G/C do gene IL-6 na síndrome coronariana aguda no nordeste do Brasil

Viviane do Carmo Vasconcelos de Carvalho; Lílian Caroliny Amorim Silva; Roberto Pereira Werkhauser; Sérgio Tavares Montenegro; Carlos Gustavo Regis da Silva; Adriana Vieira Gomes; Clarice Neuenschwander Lins de Morais; Silvia Maria Lucena Montenegro

Int J Cardiovasc Sci.2016;29(4):288-294 : Original Article

Abstract PDF PORT PDF ENGLISH

BACKGROUND: Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. It is a multifactorial disease caused by obstruction of the coronary arteries by atheromatous plaques and leads to heart ischemia. Several studies suggest that some genetic polymorphisms change the cytokines levels and influence ACS development.
OBJECTIVE: In this study, we evaluated the IL-6 (-174G/C) polymorphism, serum levels of cytokine and its relationship with ACS and the thrombolysis in myocardial infarction (TIMI) risk score.
MATERIALS AND METHODS: A sample of 200 patients with ACS [TIMI risk - Low (70); Intermediate (89); High (41)] in Brazilian population was used. Genotyping was carried out by polymerase chain reaction, followed by DNA sequencing.
RESULTS: There was no significant differences in genotype (p = 0.53) and allele (p = 0.32) distributions between ACS patient and without ACS patients groups on IL-6 allelic polymorphism and between the three differents TIMI risk score (p > 0.05). Moreover IL-6 polymorphism did not affect the cytokine levels and these levels were not related to TIMI score.
CONCLUSIONS: With these results, we suggest that the IL-6 (-174 G/C) polymorphism, until now, is not related to ACS and did not change the levels of the cytokine in studied population. Further studies with different populations should be done to verify those results. It is important to emphasize that, since ACS is a multifactorial disease, other risk factors and other pro-inflammatory cytokines should be assessed to better understand this pathology. (Int J Cardiovasc Sci. 2016;29(4):288-294)


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