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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647

Article's Author

4 result(s) for: Leonardo Silva Roever Borges

Coronary microvascular dysfunction

Disfunção coronariana microvascular

Leonardo Silva Roever Borges; Elmiro Santos Resende

Int J Cardiovasc Sci.2015;28(2):152-159 : Update Article


In the last two decades, a number of studies reported that abnormalities in the coronary microcirculation function and structure may occur in patients without obstructive atherosclerosis, in patients with risk factors, with myocardial diseases, as well as in obstructive atherosclerosis. Coronary microvascular coronary dysfunction may be iatrogenic and is an important risk marker, contributing to the pathogenesis of cardiovascular and myocardial diseases. Due to its importance, it becomes a therapeutic target. This article presents an update on the clinical relevance of coronary microvascular dysfunction in different clinical situations.

Clinical applications and methods of intravascular imaging of atherosclerosis

Aplicações clínicas e métodos de imagem intravascular da aterosclerose

Leonardo Silva Roever Borges; Cláudio Tinoco Mesquita

Int J Cardiovasc Sci.2016;29(3):223-232 : Review Article


Atherosclerosis is the leading cause of coronary artery disease, stroke and peripheral artery disease. The onset of atherosclerotic coronary lesions occurs through accumulation and oxidation of low-density lipoprotein (LDL). Oxidized LDL promotes the recruitment and activation of leukocytes, as well as cell death and generation of complex atherosclerotic plaques. These plaques have high necrotic core content, a thin fibrous inflamed layer, and intense accumulation of macrophages. In the initial stage of the formation of atheroma, remodeling of the vessel wall generally prevents the plate from invading the lumen, thereby masking the presence of atheroma in angiography. Advances have contributed to the study of atherosclerosis by intravascular imaging. Methods such as intravascular ultrasound, optical coherence tomography, intravascular magnetic resonance spectroscopy, infrared spectroscopy, Raman spectroscopy, fluorescence spectroscopy, intravascular magnetic resonance imaging and infrared fluorescence have been used in the intravascular evaluation of atherosclerosis. Intravascular ultrasound can assess the extent of the disease in the axial and longitudinal plane and contribute to the understanding of the pathophysiology of coronary artery disease. This manuscript describes the characteristics and clinical applications of the methods of coronary intravascular imaging.

Diagnostic accuracy measures in cardiovascular research

Medidas de acurácia diagnóstica na pesquisa cardiovascular

Leonardo Silva Roever Borges

Int J Cardiovasc Sci.2016;29(3):218-222 : Review Article


Diagnostic accuracy is the ability of a test to discriminate between the target condition and health; it can be quantitated using diagnostic accuracy measures such as sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, the area under the ROC curve, odds ratio of the diagnosis and Youden index. The diagnostic accuracy measures are related to the different aspects of the diagnostic procedure. Some measures are used to evaluate the discriminative property of the test, while others are used to assess its predictive ability. Diagnostic accuracy measures are not fixed indicators of a test performance; some are very sensitive to disease prevalence, while others are sensitive to disease spectrum and definition. This review described the definitions and characteristics of diagnostic accuracy measures used in cardiovascular research.

Understanding meta-epidemiological studies

Compreendendo os estudos de meta-epidemiologia

Leonardo Silva Roever Borges

Int J Cardiovasc Sci.2016;29(4):326-328 : Point of View


The concept of meta-epidemiology has been introduced because of the methodological limitations of the systematic review of clinical trials of intervention. Meta-epidemiology has moved from a statistical method to a new methodology to close gaps between evidence and practice, controlling the potential biases in quantitative systematic review and drawing appropriate evidence to establish evidence-based guidelines. Network meta-epidemiology has been suggested to overcome some limitations of meta-epidemiology. This review aims to clarify the concept and major methods to conduct a meta-epidemiological study.