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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647

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1 result(s) for: Diego Passos Diogo

C-reactive protein in oral contraceptive users: related factors and cardiovascular risk

Proteína C reativa em usuárias de contraceptivo oral: fatores relacionados e risco cardiovascular

Alan Carlos Nery dos Santos; Jefferson Petto; Francisco Tiago Oliveira de Oliveira; Diego Passos Diogo; Ana Marice Teixeira Ladeia

Int J Cardiovasc Sci.2016;29(4):320-325 : Review Article

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Studies show an association between the use of combined oral contraceptive (COC) and the elevation of C-reactive protein (CRP). However, it is unclear whether this increase represents cardiovascular risk, and what are the mechanisms involved in this association. Thus, our study aimed to review works that investigated the CRP levels in COC users, as well as describe the factors involved in this elevation. We considered eligible the studies indexed in EBSCO, EUROPUBMED, LILACS, PubMed and MEDLINE databases that evaluated the CRP of low-dose COC users, published between 2004 and 2015. The electronic search consisted of crossing the descriptors: Contraceptives, Oral, Combined; C-Reactive Protein and Inflammation, which resulted in 136 studies, of which 11 were eligible. They showed elevated CRP, even after ten days of use of COC. The most common CRP values were between 1-3 mg / L and > 3 mg / L, and in some studies values were greater than 10 mg / L. This indicates increased risk of future cardiovascular and metabolic events in this population. On the other hand, the main factors and mechanisms involved in the increase of this protein were hormonal, and, mainly, estrogenic and androgenic, and changes in function and levels of estrogen receptor β, high levels of cortisol and insulin resistance were documented. Other findings also indicate elevation of TNF-α, DNA hypomethylation in macrophages and alterations in the hepatic production of CRP. Finally, the COC represents, as does obesity, 20% of the variation of CRP of women of reproductive age.


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