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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647

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1 result(s) for: Alex N. Haas

Impact of periodontal disease in the lipid profile of patients with chronic coronary artery disease: a 3-year, retrospective cohort

Impacto da doença periodontal no perfil lipídico de pacientes com doença arterial coronariana crônica: uma coorte retrospectiva de 3 anos

Cassio Kampits; Cassiano K. Rösing; Marlon Munhoz Montenegro; Ingrid W. J. Ribeiro; Marco Aurelio Lumerts Saffi; Carisi A. Polanczyk; Mariana V. Furtado; Alex N. Haas

Int J Cardiovasc Sci.2016;29(4):270-279 : Original Article

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BACKGROUND: Inflammation has been recognized as an important risk factor for cardiovascular diseases. Periodontal disease may alter some plasma markers involved in the atherogenic process.
OBJECTIVE: To assess the association between periodontal disease and lipid levels over time in patients with chronic coronary artery disease.
METHODS: This retrospective cohort study included a sample of patients with chronic heart disease receiving care in an outpatient tertiary care for ischemic heart disease. Of 239 patients eligible for the study, we included 80 patients who had available retrospective data of lipid profile between 2009 and 2011. We performed periodontal examinations of all teeth present in 2011. Multiple models of generalized estimating equations were applied to assess the association between periodontal parameters and changes over time in the following outcomes: triglycerides, total cholesterol, LDL-cholesterol, and HDL-cholesterol levels adjusted for age, body mass index, smoking, use of oral hypoglycemic, and follow-up duration.
RESULTS: During a mean follow-up time of 713 days, there were no significant changes in the concentrations of triglycerides, total cholesterol, and LDL-cholesterol. A significant 31.6% increase in HDL-cholesterol levels was observed between 2009 and 2011. We observed a significant negative association between mean individual periodontal attachment loss and HDL-cholesterol levels, indicating that the greater the attachment loss, the lower the HDL-cholesterol level over time.
CONCLUSION: Destructive periodontal disease may be related to a worse lipid control, specifically regarding HDL-cholesterol levels, in chronic cardiac patients. (Int J Cardiovasc Sci. 2016;29(4):270-279)


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