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ISSN (Print): 2359-4802 | ISSN (Online): 2359-5647

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8 result(s) for: Alan Carlos Nery dos Santos

Effect of a regular aerobic exercise program on C-reactive protein among people at risk for cardiovascular disease

Efeito de um programa regular de exercício físico sobre a proteína C-reativa de indivíduos com risco de doenças cardiovasculares

Patrícia Alcântara Doval de Carvalho Viana; Jefferson Petto; Alan Carlos Nery dos Santos; Marcos Machado Barojas; Francisco Tiago Oliveira de Oliveira; Luis Cláudio Lemos Correia

Rev Bras Cardiol.2014;27(3):172-179 : Original Article

Abstract PDF PORT

BACKGROUND: Although observational studies suggest that exercise has anti-inflammatory effects, this possibility has not been confirmed definitively through randomized clinical trials.
OBJECTIVE: To assess the effects of aerobic activities on systemic inflammatory processes among people at cardiovascular risk.
METHODS: A randomized clinical trial encompassing sedentary subjects with at least two risk factors for heart disease or established cardiovascular disease. These volunteers were assigned randomly to three months of supervised aerobic training (training group) or just counseling on healthy lifestyle habits (control group). C-reactive protein (CRP) was measured by a highly sensitive method before and after these interventions.
RESULTS: Assessing 68 subjects. The training and control groups had similar baseline characteristics. There was improvement in functional capacity among only the training group patients. After three months, an increase in the CRP was noted in the control group, whose median rose from 2.2mg/L (IQR=1.0 to 4.3mg/L) to 3.2mg/L (IQR=2.4 to 5.5mg/L) - p=0.006. This phenomenon was not found in the training group, which presented a baseline median of 1.7mg/L (IQR =0.97 to 4.8mg/L), statistically similar to the final value of 2.5mg/L (1.0 to 4.7mg/L) - p=0.46. When the percentage variation in the CRP was compared for these groups, there was a greater increase in the control group (+58%, IQR=11% to 151%), compared to the training group (+17%, IQR= -36% to 79%) - intergroup p=0.046.
CONCLUSION: An aerobic exercise program seems to lessen CRP elevation among people at cardiovascular risk.

Factors preventing referrals to supervised cardiac rehabilitation

Fatores de impedimento ao encaminhamento para a reabilitação cardíaca supervisionada

Jefferson Petto; Pollyane Lopes de Araújo; Natália da Luz Garcia; Alan Carlos Nery dos Santos; Giulliano Gardenghi

Rev Bras Cardiol.2013;26(5):364-368 : Original Article

Abstract PDF PORT

BACKGROUND: Supervised cardiac rehabilitation (SCR) is designed to help heart disease patients rejoin society, with lower treatment costs. However, the number of people with heart disease undergoing SCR is still low, mainly because few cardiologists refer their patients.
OBJECTIVE: To identify the reasons why cardiologists do not refer their patients to SCR facilities.
METHODS: A sample of 81 cardiologists in Salvador, Bahia State, Brazil completed a self-administered questionnaire consisting of objective questions exploring basic concepts and prescriptions of SCR.
RESULTS: Of these 81 cardiologists, 67 (82 %) state that they recommend SCR, of whom 25 (37 %) and 17 (25 %) reported that they do not refer their patients in some situations: not knowing an SCR center and believing that their patient profiles were not suitable, respectively. Among the 67 practitioners recommending SCR, 45 (67 %) stated that they did know any rehabilitation centers. Together, cardiologists not recommending SCR and recommending it but not knowing an SCR center for patient referrals totaled 56 (70 %).
CONCLUSION: Only a small proportion of cardiologists in Salvador, Bahia State, Brazil recommend SCR, with the main stumbling-block being their lack of knowledge about SCR centers for referring their patients.

Subclinical inflammation in women taking oral contraceptives

Inflamação subclínica em mulheres que utilizam contraceptivo oral

Jefferson Petto; Leandro Silva Pereira; Alan Carlos Nery dos Santos; Beatriz de Almeida Giesta; Thiago Araújo de Melo; Ana Marice Teixeira Ladeia

Rev Bras Cardiol.2013;26(6):465-471 : Original Article

Abstract PDF PORT

BACKGROUND: Recent studies show that women taking oral contraceptives (OC) have higher triglyceride and low-density lipoprotein levels than women not taking CO. Although the long-term clinical consequences of this increase are still unknown, studies suggest that higher levels of low-density lipoproteins contribute directly to vascular inflammation. One of the most effective ways of measuring vascular inflammation is through high sensitivity C-reactive protein (CRP).
OBJECTIVE: To examine whether the CRP levels of women taking OC are higher than those of women not taking OC.
METHODS: Study conducted at the Bahia Social Work College, Salvador, Bahia State - Brazil between July and December 2012, including apparently healthy women between 18 and 28 years old, eutrophic, classified as irregularly active and with fasting triglycerides below 150mg/dL. The sample was divided into two groups: an NOC group of women who not taking any type of hormone-based contraceptive and an OC group of women taking continuous low-dose OC for at least one year. After fasting for 12 hours, 5mL of blood were collected to measure their CRP levels.
RESULTS: 44 women were selected and divided equally between the groups, aged 24.0±2.9, BMI 21.0±3.2kg/m2. The median and interquartile CRP deviations in the NOC group and the OC group were respectively 0.5mg/L (0.0 to 0.9) and 2.1mg/L (0.9 to 3.2), with a statistically significant difference (p=0.002).
CONCLUSION: In this study, the CRP levels of women taking oral contraceptives were significantly higher than those of women not taking oral contraceptives.

C-Reactive protein in the initial phase of postprandial lipemia in subjects with central obesity

Proteína C-Reativa na fase inicial da lipemia pós-prandial em indivíduos com obesidade central

Djeyne Silveira Wagmacker; Jefferson Petto; Fabiano Leichsenring Silva; Alan Carlos Nery dos Santos; Ana Marice Teixeira Ladeia

Int J Cardiovasc Sci.2015;28(1):9-15 : Original Article


BACKGROUND: Studies indicate that during postprandial lipemia (PPL), free radical formation occurs, stimulating the endothelium to secrete cytokines that mediate inflammatory responses. Excess adipose tissue, especially in the abdominal region, is positively correlated with C-reactive protein (CRP) values. However, little is known about CRP variations during the initial phase of PPL, especially among obese individuals.
OBJECTIVE: To determine if there are variations in CRP plasma concentrations among individuals with central obesity during the initial phase of PPL.
METHODS: This study assessed forty sedentary men and women with no alterations to fasting lipid profiles and waist circumferences above the normal cutoff point, measuring their CRP levels after fasting for twelve hours and three hours after ingesting 50g of fat.
RESULTS: The mean CRP values after fasting and three hours after lipids intake were 0.6 mg/L (0.2 to 1.8 mg/L) and 0.4 mg/L (0.2 to 1.8 mg/L) (p=1.000) respectively.
CONCLUSION: In this study, the initial phase of PPL did not present any variations in CRP concentrations among subjects with central obesity.

Postprandial lipemia and subclinical inflammation on active women taking oral contraceptive

Lipemia pós-prandial e inflamação subclínica em mulheres ativas que utilizam contraceptivo oral

Jefferson Petto; Djeyne Wagmacker Silveira; Alan Carlos Nery dos Santos; Candice Rocha Seixas; Douglas Gibran Cerqueira do Espirito Santo; Francisco Tiago Oliveira de Oliveira; Cleber Santos Luz; Ana Marice Teixeira Ladeia

Int J Cardiovasc Sci.2015;28(3):215-223 : Original Article


BACKGROUND: Women taking oral contraceptives (OC) have higher fasting lipid profile, postprandial lipemia (PPL) and C-reactive protein (CRP) than women not taking OC. Exercise has shown good results in controlling lipid and inflammatory levels.
OBJECTIVE: To compare fasting lipid, PPL and CRP levels among regularly active and irregularly active women taking OC.
METHODS: The study evaluated forty-four women taking OC, from the city of Salvador, BA, stratified into two groups: active group (AG; n=22), composed of physically active women and irregularly active group (IAG; n=22) composed of irregularly active women. In both groups, after 12-hour fasting, fasting lipid profile and CRP were assessed. Then, the volunteers took a compound containing 25 g fat and triglycerides were measured to check PPL. Mann-Whitney's test was used to compare PPL and CRP.
RESULTS: The delta values of triglycerides representing PPL respectively for the AG and the IAG were: 93±38.4 mg/dL vs. 163±49.6 mg/dL and 89±50.9 mg/dL vs. 156±47.6 mg/dL (p<0.01). The CRP values respectively for the AG and the IAG were: 1.1 mg/L (0.4-2.1 mg/L) and 2.1 mg/L (0.8-3.4 mg/L) (p=0.04).
CONCLUSION: In this study, physically active women taking OC presented triglycerides and fasting LDL, PPL and CRP significantly lower than irregularly active women taking OC.

Adiponectin: characterization, metabolic and cardiovascular action

Adiponectina: caracterização, ação metabólica e cardiovascular

Jefferson Petto; Alan Carlos Nery dos Santos; Marcelo Trotte Motta; Roberto Santos Teixeira Filho; Douglas Gibran Cerqueira do Espirito Santo; José Lázaro Lins Ribas; Ana Marice Teixeira Ladeia

Int J Cardiovasc Sci.2015;28(5):424-432 : Review Article


In the last two decades, the understanding of adipose tissue biology underwent revolutionary changes, from a major energy storage site to an important endocrine organ responsible for the production and secretion of proteins, peptides and non-bioactive peptides. Among the proteins secreted by adipocytes, adiponectin (APN) is the most abundant, with important physiological actions in the cardiovascular and endocrine system, involving the sensitization of insulin action and regulation of body energy metabolism, including the heart. This review aims to describe the action of APN on the cardiovascular system. It includes original manuscripts with humans or animals. The databases PubMed and Medline, from years 1994 to 2013, were searched. Case reports, pilot studies or review studies have not been included. The health science descriptors and MeSH specific for Medline were used as keywords. The following cross searches were carried out: Adiponectin AND Obesity, Adiponectin AND Metabolism and Adiponectin AND Cardiovascular Disease. We found 303 manuscripts, excluded 204 and selected 31 manuscripts that were included this study. In the general context of this review, APN presents anti-inflammatory and ateroprotector effects in the vascular tissue and an insulin sensitizing action in tissues involved in glucose and lipid metabolism. It is thus considered an important biomarker for the development of cardiovascular diseases.

Importance of academic quality in the treatment of chronic venous insufficiency

Importância da qualidade da formação acadêmica no tratamento da insuficiência venosa crônica

Jefferson Petto; Vinícius Afonso Gomes; Francisco Tiago Oliveira de Oliveira; Marcos Paulo Alves dos Santos; Paulo Ricardo Pinto Barbosa; Alan Carlos Nery dos Santos

Int J Cardiovasc Sci.2016;29(1):31-36 : Original Article


BACKGROUND: Studies have shown limitations in the knowledge of academics and health professionals on a variety of clinical conditions. However, there is little research in the field of cardiovascular sciences.
OBJECTIVE: To identify and describe the level of knowledge of Physiotherapy graduates on chronic venous insufficiency (CVI).
METHODS: Descriptive cross-sectional observational study with graduates in the last year of physiotherapy undergraduate studies randomly selected from six higher education institutions. Data were collected through a self-administered structured questionnaire addressing academic education, clinical aspects and physiotherapy interventions on CVI. The students were grouped into: FSDA - universities where Angiology is not taught; FPNE - universities where a non-specialist professor teaches Angiology; and FPE - universities where a specialist professor teaches Angiology.
RESULTS: The evaluation covered 101 graduates. Of these, only 4.9% were familiar with of all the techniques and methods to diagnose CVI and 44.0% did not mention clinical examination as diagnostic evaluation. Of the 35 FPNE students, 18 (51.0%) did not mention clinical examination and 31.0% mentioned incorrect CVI diagnosing methods. Of the 19 FSDA students, 74.0% did not choose elastic compression as a means of treatment.
CONCLUSION: It was concluded that the evaluated graduates presented little knowledge on the main physiotherapy treatments and diagnostic methods for chronic venous insufficiency.

C-reactive protein in oral contraceptive users: related factors and cardiovascular risk

Proteína C reativa em usuárias de contraceptivo oral: fatores relacionados e risco cardiovascular

Alan Carlos Nery dos Santos; Jefferson Petto; Francisco Tiago Oliveira de Oliveira; Diego Passos Diogo; Ana Marice Teixeira Ladeia

Int J Cardiovasc Sci.2016;29(4):320-325 : Review Article


Studies show an association between the use of combined oral contraceptive (COC) and the elevation of C-reactive protein (CRP). However, it is unclear whether this increase represents cardiovascular risk, and what are the mechanisms involved in this association. Thus, our study aimed to review works that investigated the CRP levels in COC users, as well as describe the factors involved in this elevation. We considered eligible the studies indexed in EBSCO, EUROPUBMED, LILACS, PubMed and MEDLINE databases that evaluated the CRP of low-dose COC users, published between 2004 and 2015. The electronic search consisted of crossing the descriptors: Contraceptives, Oral, Combined; C-Reactive Protein and Inflammation, which resulted in 136 studies, of which 11 were eligible. They showed elevated CRP, even after ten days of use of COC. The most common CRP values were between 1-3 mg / L and > 3 mg / L, and in some studies values were greater than 10 mg / L. This indicates increased risk of future cardiovascular and metabolic events in this population. On the other hand, the main factors and mechanisms involved in the increase of this protein were hormonal, and, mainly, estrogenic and androgenic, and changes in function and levels of estrogen receptor β, high levels of cortisol and insulin resistance were documented. Other findings also indicate elevation of TNF-α, DNA hypomethylation in macrophages and alterations in the hepatic production of CRP. Finally, the COC represents, as does obesity, 20% of the variation of CRP of women of reproductive age.